Ablim2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in myofibril. Is expressed in several structures, including brain; diaphragm; early conceptus; oocyte; and skeletal muscle. Orthologous to human ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ablim2 |
| Official Name | actin-binding LIM protein 2 [Source:MGI Symbol;Acc:MGI:2385758] |
| Ensembl ID | ENSMUSG00000029095 |
| Bio databases IDs | |
| Aliases | actin-binding LIM protein 2 |
| Synonyms | actin-binding LIM protein 2, actin binding LIM protein family member 2, actin binding LIM protein family, member 2, C230091L11, LOC100128350 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ablim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- Villin headpiece domain
- protein binding
- Putative adherens-junction anchoring region of AbLIM
Pathways
Biological processes and signaling networks where the Ablim2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic carcinoma
- pancreatic epithelial cancer
- Huntington disease
- irritable bowel syndrome
- aggressive periodontitis
- diffuse gastric cancer
- pervasive developmental disorder
- COVID-19
- vascular dementia
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- TAGLN
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ablim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- lamellipodium assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- metal ion binding