Nhlrc3 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in embryo. Orthologous to human NHLRC3 (NHL repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nhlrc3 |
| Official Name | NHL repeat containing 3 [Source:MGI Symbol;Acc:MGI:2444520] |
| Ensembl ID | ENSMUSG00000042997 |
| Bio databases IDs | |
| Aliases | NHL repeat containing 3 |
| Synonyms | 4833441N19, 8030451K01Rik, mKIAA4083, NHL repeat containing 3, RGD1565414 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nhlrc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHL repeat
- NHL repeat unit of beta-propeller proteins
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nhlrc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- translation repressor activity