Tnfsf9 Gene Summary [Mouse]
Enables tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within regulation of immature T cell proliferation in thymus. Located in plasma membrane. Is expressed in bone; connective tissue; hip; and metanephros. Orthologous to human TNFSF9 (TNF superfamily member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf9 |
| Official Name | tumor necrosis factor (ligand) superfamily, member 9 [Source:MGI Symbol;Acc:MGI:1101058] |
| Ensembl ID | ENSMUSG00000035678 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor (ligand) superfamily, member 9 |
| Synonyms | 4-1BB-L, 4-IBB-L, CD137L, Ly63l, TNF superfamily member 9, TNLG5A, tumor necrosis factor (ligand) superfamily, member 9, tumour necrosis factor (ligand) superfamily, member 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfsf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- cytoplasmic domain
- TNF
- intracellular domain
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Tnfsf9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- systemic lupus erythematosus
- tumor
- adenoma formation
- benign neoplasia
- Marfan syndrome
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- lymphomagenesis
role in cell
- proliferation
- cell death
- apoptosis
- production in
- expression in
- differentiation
- activation in
- glycolysis in
- survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfsf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- immune response
- positive regulation of cytotoxic T cell differentiation
- signal transduction
- cell-cell signaling
- regulation of apoptotic process
- positive regulation of activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor superfamily binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding