Ddost Gene Summary [Mouse]
Predicted to enable enzyme activator activity. Predicted to be involved in several processes, including T cell activation; protein N-linked glycosylation via asparagine; and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddost |
| Official Name | dolichyl-di-phosphooligosaccharide-protein glycotransferase [Source:MGI Symbol;Acc:MGI:1194508] |
| Ensembl ID | ENSMUSG00000028757 |
| Bio databases IDs | |
| Aliases | dolichyl-di-phosphooligosaccharide-protein glycotransferase |
| Synonyms | AGE-R1, CDG1R, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, dolichyl-di-phosphooligosaccharide-protein glycotransferase, GATD6, LOC100504754, OKSWcl45, OST, OST48, WBP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddost often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- Oligosaccharyltransferase 48 kDa subunit beta
- enzyme
- protein binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- congenital disorder of glycosylation type 1R
- aldosterone producing adrenocortical adenoma
- ocular hypertension
- infection by HIV-1
- productive infection by HIV-1
role in cell
- phosphorylation in
- expression in
- activation
- aggregation in
- N-glycosylation in
- binding in
- transactivation in
- recruitment
- oligomerization in
- epithelial-mesenchymal transition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cell surface
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- inner nuclear membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddost gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- regulation of protein stability
- T cell activation
- protein glycosylation
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity