Mr1 Gene Summary [Mouse]
Predicted to enable T cell receptor binding activity and beta-2-microglobulin binding activity. Involved in T cell differentiation in thymus and defense response to Gram-negative bacterium. Predicted to be located in endoplasmic reticulum membrane; endosome membrane; and plasma membrane. Predicted to be part of MHC class I protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MR1 (major histocompatibility complex, class I-related). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mr1 |
| Official Name | major histocompatibility complex, class I-related [Source:MGI Symbol;Acc:MGI:1195463] |
| Ensembl ID | ENSMUSG00000026471 |
| Bio databases IDs | |
| Aliases | major histocompatibility complex, class I-related |
| Synonyms | H2ls, HLALS, major histocompatibility complex, class I-related |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- immunoglobulin domain
- T-cell receptor binding
- protein binding
- transmembrane receptor
- MHC class I receptor
- beta-2-microglobulin binding
Pathways
Biological processes and signaling networks where the Mr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antigen Presentation Pathway
- Communication between Innate and Adaptive Immune Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Neuroinflammation Signaling Pathway
- Nur77 Signaling in T Lymphocytes
- Phagosome Maturation
- Protein Ubiquitination Pathway
- T Cell Receptor Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- beta-thalassemia major
- liver disease
- infection
- insulin-dependent diabetes mellitus
- graft rejection
- myelodysplastic syndrome
- acute myeloid leukemia
- treatment-related acute myeloid leukemia
- experimental autoimmune encephalomyelitis
- relapsing multiple sclerosis
role in cell
- development
- apoptosis
- activation
- differentiation
- recruitment
- bacterial load
- function
- abnormal number
- viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of T cell mediated cytotoxicity directed against tumor cell target
- defense response to Gram-negative bacterium
- T cell differentiation in thymus
- innate immune response
- antigen processing and presentation of exogenous antigen
- antigen processing and presentation of peptide antigen via MHC class I
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- late endosome membrane
- extracellular space
- external side of plasma membrane
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
- MHC class I protein complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- MHC class I receptor activity
- T cell receptor binding
- beta-2-microglobulin binding