Twf2 Gene Summary [Mouse]
Enables actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping. Located in several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Twf2 |
| Official Name | twinfilin actin binding protein 2 [Source:MGI Symbol;Acc:MGI:1346078] |
| Ensembl ID | ENSMUSG00000023277 |
| Bio databases IDs | |
| Aliases | twinfilin actin binding protein 2 |
| Synonyms | A6r, A6-related, A6RP, MSTP011, PTK9L, Ptk9r, Twinfilin 2, twinfilin actin-binding protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Twf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- actin monomer binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein kinase C binding
- ATP binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- bleeding
- colon epithelial cancer
- osteoarthritis
- colon carcinoma
- schizophrenia
- bipolar disorder
- diverticular disease
- macrothrombocytopenia
role in cell
- activation in
- lifespan
- actin capping
- length
- cell spreading
- assembly
- response by
- formation by
- extension
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- stereocilia tip
- perinuclear region
- cytosol
- stereocilia
- growth cone
- myofibrils
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Twf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- regulation of lamellipodium assembly
- sequestering of actin monomers
- actin filament depolymerization
- cell projection organization
- positive regulation of axon extension
- barbed-end actin filament capping
- regulation of actin cytoskeleton organization
- negative regulation of actin filament polymerization
- cellular response to retinoic acid
- cellular response to growth factor stimulus
- regulation of microvillus length
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- filopodium
- stereocilium
- actin filament
- myofibril
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- actin filament binding
- ATP binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- RNA binding
- cadherin binding
- actin monomer binding