Phc2 Gene Summary [Mouse]
Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phc2 |
| Official Name | polyhomeotic 2 [Source:MGI Symbol;Acc:MGI:1860454] |
| Ensembl ID | ENSMUSG00000028796 |
| Bio databases IDs | |
| Aliases | polyhomeotic 2 |
| Synonyms | A3galt2, D130050K19RIK, D4Ertd810e, EDR2, HPH2, Mph2, p36, PH2, polyhomeotic 2, polyhomeotic homolog 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Family of unknown function (DUF5585)
- Unstructured region on Polyhomeotic-like protein 1 and 2
- SAM (Sterile alpha motif )
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- inflammatory bowel disease
- Alzheimer disease
- diabetes mellitus
- ulcerative colitis
- schizophrenia
- non-insulin-dependent diabetes mellitus
role in cell
- proliferation
- replicative senescence
- premature senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- PRC1 complex
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- identical protein binding
- protein binding
- histone binding
- chromatin binding