Olfr78 Gene Summary [Mouse]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Olfr78 |
| Official Name | olfactory receptor 78 [Source:MGI Symbol;Acc:MGI:2157548] |
| Ensembl ID | ENSMUSG00000043366 |
| Bio databases IDs | |
| Aliases | olfactory receptor 78 |
| Synonyms | 4633402A21Rik, HPRAJ, MOL2.3, MOR18-2, olfactory receptor 59, olfactory receptor family 51 subfamily E member 2, Olfr78, Olr59, OR51E3P, OR52A2, PSGR, RA1c |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Olfr78 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- olfactory receptor
- signaling receptor activity
- steroid hormone receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thromboembolism
- cancer
- epithelial neoplasia
- prostate cancer
- prostatic neoplasia
- pelvic cancer
- urogenital cancer
- abdominal cancer
- epithelial cancer
- prostatic intraepithelial neoplasm
role in cell
- expression in
- proliferation
- differentiation
- growth
- activation in
- migration
- response by
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- organelle
- cell surface
- cellular membrane
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Olfr78 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanocyte differentiation
- cellular response to fatty acid
- positive regulation of renin secretion into blood stream
- detection of chemical stimulus involved in sensory perception of smell
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- steroid hormone mediated signaling pathway
- cell migration
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- signaling receptor activity
- steroid hormone receptor activity
- olfactory receptor activity