Hexim2 Gene Summary [Mouse]
Predicted to enable 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Predicted to be involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in heart and skeletal muscle. Orthologous to human HEXIM2 (HEXIM P-TEFb complex subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hexim2 |
| Official Name | hexamethylene bis-acetamide inducible 2 [Source:MGI Symbol;Acc:MGI:1918309] |
| Ensembl ID | ENSMUSG00000043372 |
| Bio databases IDs | |
| Aliases | hexamethylene bis-acetamide inducible 2 |
| Synonyms | 4933402L21Rik, FLJ32384, hexamethylene bis-acetamide inducible 2, HEXIM P-TEFb complex subunit 2, L3, RGD1311635 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hexim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- snRNA binding
- transcription regulator
- Hexamethylene bis-acetamide-inducible protein
- protein binding
- Cell division protein ZapB
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hexim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- snRNA binding
- cyclin-dependent protein kinase inhibitor activity