HEXIM2 Gene Summary [Human]
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | HEXIM2 |
| Official Name | HEXIM P-TEFb complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28591] |
| Ensembl ID | ENSG00000168517 |
| Bio databases IDs | |
| Aliases | HEXIM P-TEFb complex subunit 2 |
| Synonyms | 4933402L21Rik, FLJ32384, hexamethylene bis-acetamide inducible 2, HEXIM P-TEFb complex subunit 2, L3, RGD1311635 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HEXIM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- snRNA binding
- transcription regulator
- Hexamethylene bis-acetamide-inducible protein
- protein binding
- Cell division protein ZapB
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HEXIM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- snRNA binding
- cyclin-dependent protein kinase inhibitor activity