Zfp536 Gene Summary [Mouse]
Enables retinoic acid-responsive element binding activity. Acts upstream of or within negative regulation of neuron differentiation and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; future brain; genitourinary system; nervous system; and sensory organ. Orthologous to human ZNF536 (zinc finger protein 536). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp536 |
| Official Name | zinc finger protein 536 [Source:MGI Symbol;Acc:MGI:1926102] |
| Ensembl ID | ENSMUSG00000043456 |
| Bio databases IDs | |
| Aliases | zinc finger protein 536 |
| Synonyms | 9630010P11Rik, KIAA0390, mKIAA0390, RGD1563363, Zfp536, zinc finger protein 536 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp536 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- CtBP binding domain
- zinc finger
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- sequence-specific DNA binding
- Unstructured conserved, between two C2H2-type zinc-fingers
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- glioblastoma
- glioblastoma cancer
- COVID-19
- metabolic syndrome X
- postural instability
- myocardial infarction
- age-related hearing loss
- schizophrenia
- malaria
phenotypes
- abnormal embryo size
- decreased blood urea nitrogen level
- decreased vertical activity
- increased circulating chloride level
- increased hemoglobin content
- increased mean corpuscular hemoglobin concentration
- increased prepulse inhibition
- preweaning lethality complete penetrance
- respiratory system phenotype
- abnormal locomotor activation
- abnormal mean corpuscular hemoglobin concentration
role in cell
- expression in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp536 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of retinoic acid receptor signaling pathway
- negative regulation of neuron differentiation
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- retinoic acid-responsive element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity