Sp100 Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromo shadow domain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including innate immune response; regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be part of Mre11 complex. Is expressed in eye; olfactory placode; and otic pit. Orthologous to human SP100 (SP100 nuclear antigen). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sp100 |
| Official Name | nuclear antigen Sp100 [Source:MGI Symbol;Acc:MGI:109561] |
| Ensembl ID | ENSMUSG00000026222 |
| Bio databases IDs | |
| Aliases | nuclear antigen Sp100 |
| Synonyms | A430075G10Rik, lysp100b, nuclear antigen Sp100, SP100 nuclear antigen, Speckled 100 kDa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sp100 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KDWK domain
- protein dimerization
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- PHD zinc finger
- transcription regulator
- dimerization domain
- Sumoylation motif
- high mobility group (HMG)-box domain superfamily
- transcription co-repressor
- transcription factor binding
- protein domain specific binding
- protein binding
- Bromodomain
- identical protein binding
- HSR domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- kinase binding
- homodimerization domain
- high mobility group
- protein homodimerization
- PHD finger superfamily
- SAND domain
Pathways
Biological processes and signaling networks where the Sp100 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Alzheimer disease
- T-cell non-Hodgkin disease
- COVID-19
- neoplastic cell transformation
- neonatal late-onset sepsis
- peripheral T-cell lymphoma
- mature T-cell neoplasia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- idiopathic inflammatory myopathy
role in cell
- expression in
- activation in
- migration
- acetylation in
- invasion
- migration by
- hydrolysis in
- transactivation in
- accumulation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear matrix fraction
- ND10 structure
- Cytoplasm
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sp100 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein export from nucleus
- interferon-gamma-mediated signaling pathway
- response to interferon-gamma
- response to type I interferon
- regulation of angiogenesis
- telomere maintenance
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- type I interferon-mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- maintenance of protein location
- negative regulation of DNA binding
- DNA damage response, signal transduction by p53 class mediator
- negative regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- PML body
- cytoplasm
- Mre11 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein domain specific binding
- protein binding
- chromo shadow domain binding
- protein dimerization activity
- kinase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity