DACT1 Gene Summary [Human]
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Processed Transcript |
| Official Symbol | DACT1 |
| Official Name | dishevelled binding antagonist of beta catenin 1 [Source:HGNC Symbol;Acc:HGNC:17748] |
| Ensembl ID | ENSG00000165617 |
| Bio databases IDs | |
| Aliases | dishevelled binding antagonist of beta catenin 1 |
| Synonyms | 4921528D17Rik, DAPPER, DAPPER1, dishevelled-binding antagonist of beta-catenin 1, dishevelled-binding antagonist of β-catenin 1, DPR1, Frd1, FRODO, Frodo1, HDPR1, MDpr1, MTNG3, RGD1564008, TBS2, THYEX3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DACT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- Dapper
- beta-catenin binding
- protein kinase C binding
- transcription factor binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- infiltrating ductal breast carcinoma
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- atresia
- hydronephrosis
- hypoplasia
- hydrometrocolpos
- caudal agenesis
- Townes-Brocks syndrome 2
role in cell
- migration
- expression in
- degradation in
- accumulation in
- invasion by
- binding in
- cell proliferation
- signaling in
- ubiquitination in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DACT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- positive regulation of protein binding
- embryonic hindgut morphogenesis
- regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of protein catabolic process
- negative regulation of JNK cascade
- negative regulation of protein binding
- regulation of nodal signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- regulation of protein stability
- regulation of canonical Wnt receptor signaling pathway
- negative regulation of G1/S transition of mitotic cell cycle
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- cytoplasm
- cytosol
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- delta-catenin binding
- protein binding
- histone deacetylase binding
- beta-catenin binding
- protein kinase A binding