Atg14 Gene Summary [Mouse]
Predicted to enable GTPase binding activity; phosphatidylinositol 3-kinase regulator activity; and protein-membrane adaptor activity. Involved in autophagy; cellular response to glucose starvation; and regulation of protein phosphorylation. Acts upstream of or within defense response to virus; innate immune response; and regulation of triglyceride metabolic process. Located in axoneme; mitochondria-associated endoplasmic reticulum membrane contact site; and phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in cerebral cortex. Orthologous to human ATG14 (autophagy related 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg14 |
| Official Name | autophagy related 14 [Source:MGI Symbol;Acc:MGI:1261775] |
| Ensembl ID | ENSMUSG00000037526 |
| Bio databases IDs | |
| Aliases | autophagy related 14 |
| Synonyms | 4832427M01, ATG14L, autophagy related 14, BARKOR, D14Ertd114e, D14Ertd436e, KIAA0831, LOC102546754, RGD1304610 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- enzyme binding
- coiled-coil domain
- Vacuolar sorting 38 and autophagy-related subunit 14
- phosphoinositide 3-kinase regulator
- protein binding
Pathways
Biological processes and signaling networks where the Atg14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertriglyceridemia
role in cell
- cell death
- autophagy by
- formation in
- number
- assembly
- response
- formation
- response by
- synthesis in
- disappearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- axonemes
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- isolation membranes
- autophagic vacuoles
- phagosomes
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-3-phosphate biosynthetic process
- endosome to lysosome transport
- cellular response to starvation
- protein targeting to lysosome
- macromitophagy
- cellular response to glucose starvation
- posttranscriptional regulation of gene expression
- autophagic vacuole assembly
- protein kinase B signaling cascade
- regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- autophagic vacuole docking
- early endosome to late endosome transport
- positive regulation of protein phosphorylation
- regulation of macroautophagy
- regulation of triglyceride metabolic process
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- phosphatidylinositol 3-kinase complex, class III
- phagocytic vesicle
- cytosol
- ER-mitochondrion membrane contact site
- autophagic vacuole
- axoneme
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase regulator activity
- protein binding
- protein anchor
- GTPase binding