Macir Gene Summary [Mouse]
Acts upstream of or within negative regulation of cytokine production involved in inflammatory response; negative regulation of epithelial cell migration; and negative regulation of fibroblast migration. Predicted to be located in ciliary transition zone and cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Macir |
| Official Name | macrophage immunometabolism regulator [Source:MGI Symbol;Acc:MGI:1277184] |
| Ensembl ID | ENSMUSG00000044768 |
| Bio databases IDs | |
| Aliases | macrophage immunometabolism regulator |
| Synonyms | C5orf30, D1Ertd622e, LOC90355, macrophage immunometabolism regulator, RGD1562136 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Macir often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UNC119-binding protein C5orf30 homolog
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary transition zone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Macir gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cilium morphogenesis
- negative regulation of inflammatory response
- protein transport
- negative regulation of epithelial cell migration
- negative regulation of fibroblast migration
- negative regulation of cytokine production involved in inflammatory response
- fibroblast migration
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- protein binding