MACIR Gene Summary [Human]
This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019]
Details
| Type | Protein Coding |
| Official Symbol | MACIR |
| Official Name | macrophage immunometabolism regulator [Source:HGNC Symbol;Acc:HGNC:25052] |
| Ensembl ID | ENSG00000181751 |
| Bio databases IDs | |
| Aliases | macrophage immunometabolism regulator, UNC119-binding protein |
| Synonyms | C5orf30, D1Ertd622e, LOC90355, macrophage immunometabolism regulator, RGD1562136 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MACIR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UNC119-binding protein C5orf30 homolog
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary transition zone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MACIR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cilium morphogenesis
- negative regulation of inflammatory response
- protein transport
- negative regulation of epithelial cell migration
- negative regulation of fibroblast migration
- negative regulation of cytokine production involved in inflammatory response
- fibroblast migration
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- protein binding