Taf7l Gene Summary [Mouse]
Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Acts upstream of or within flagellated sperm motility and spermatid development. Located in cytoplasm and male germ cell nucleus. Is expressed in bladder; brown fat; ovary; testis; and ureter. Orthologous to human TAF7L (TATA-box binding protein associated factor 7 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf7l |
| Official Name | TATA-box binding protein associated factor 7 like [Source:MGI Symbol;Acc:MGI:1921719] |
| Ensembl ID | ENSMUSG00000009596 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 7 like |
| Synonyms | 4933438I11Rik, CT40, RGD1564898, TAF2Q, TATA-box binding protein associated factor 7-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf7l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- TATA binding protein associated factor 7
Pathways
Biological processes and signaling networks where the Taf7l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- atopic dermatitis
- asthenozoospermia
- hairpin sperm flagellum
- oligozoospermia
role in cell
- quantity
- function
- differentiation
- number
- development
- morphology
- motility
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf7l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIID complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- general RNA polymerase II transcription factor activity