Tnpo1 Gene Summary [Mouse]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnpo1 |
| Official Name | transportin 1 [Source:MGI Symbol;Acc:MGI:2681523] |
| Ensembl ID | ENSMUSG00000009470 |
| Bio databases IDs | |
| Aliases | transportin 1 |
| Synonyms | AU021749, D13Ertd688e, Importin beta 2, Importin β 2, IPO2, KAP beta 2A, KAP β 2, KAP β 2A, KARYOPHERIN, Karyopherin beta-2, Karyopherin β-2, KPNB2, MIP, MIP1, TRANSPORTIN-1, TRN, TRN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnpo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- HEAT-like repeat
- protein binding
- Importin-beta N-terminal domain
- HEAT repeats
- nuclear localization sequence binding
- transporter
Pathways
Biological processes and signaling networks where the Tnpo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- atrial fibrillation
- kidney stones
- thrombocytopenia
- urinary bladder stone
- infection by Influenza A virus subtype H1N1
role in cell
- josamycin sensitivity
- innate immune response in
- retention in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- cilia
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnpo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- small GTPase binding
- nuclear localization sequence binding