Lingo1 Gene Summary [Mouse]
Enables epidermal growth factor receptor binding activity. Acts upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including branchial arch; central nervous system; gut; sensory organ; and somite. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lingo1 |
| Official Name | leucine rich repeat and Ig domain containing 1 [Source:MGI Symbol;Acc:MGI:1915522] |
| Ensembl ID | ENSMUSG00000049556 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and Ig domain containing 1 |
| Synonyms | 4930471K13RIK, FLJ14594, LERN1, leucine rich repeat and Ig domain containing 1, LRRN6A, MRT64, UNQ201 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lingo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- epidermal growth factor receptor binding
- Immunoglobulin like
- Leucine rich repeat
- intracellular domain
- Immunoglobulin I-set domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine rich repeat N-terminal domain
Pathways
Biological processes and signaling networks where the Lingo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neuroticism
- metabolic syndrome X
- autosomal recessive mental retardation type 64
- schizophrenia
- Alzheimer disease
- diabetic nephropathy
- epileptic seizure
- Huntington disease
- depressive disorder
role in cell
- apoptosis
- differentiation
- growth
- survival
- length
- development
- replication in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- presynaptic regions
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lingo1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- epidermal growth factor receptor binding