Lhfpl2 Gene Summary [Mouse]
Involved in development of primary female sexual characteristics; development of primary male sexual characteristics; and positive regulation of fertilization. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and tail unsegmented mesenchyme. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhfpl2 |
| Official Name | lipoma HMGIC fusion partner-like 2 [Source:MGI Symbol;Acc:MGI:2145236] |
| Ensembl ID | ENSMUSG00000045312 |
| Bio databases IDs | |
| Aliases | lipoma HMGIC fusion partner-like 2 |
| Synonyms | 6030465B15, AI447312, DKFZp781E0375, FLJ43237, KIAA0206, LHFPL tetraspan subfamily member 2, lipoma HMGIC fusion partner-like 2, LOC107986425, mKIAA0206, vgim |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhfpl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- Lipoma HMGIC fusion partner-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- stroke
- COVID-19
- renal cell carcinoma
- renal cell cancer
- systemic lupus erythematosus
- abdominal aortic aneurysm
- cardiovascular disorder
- sialadenitis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhfpl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- development of primary female sexual characteristics
- development of primary male sexual characteristics
- single fertilization
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding