Iqub Gene Summary [Mouse]
Involved in flagellated sperm motility and mating. Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in acrosomal vesicle and sperm flagellum. Part of radial spoke. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; respiratory system; and thymus. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iqub |
| Official Name | IQ motif and ubiquitin domain containing [Source:MGI Symbol;Acc:MGI:3041159] |
| Ensembl ID | ENSMUSG00000046192 |
| Bio databases IDs | |
| Aliases | IQ motif and ubiquitin domain containing |
| Synonyms | 4932408B21Rik, IQ motif and ubiquitin domain containing, LOC100503287, N-WASP, RGD1562359, TRS4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iqub often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- VCA domain
- protein binding
- Arp binding domain
- acidic domain
- polyproline motif
- proline rich domain
- Ubiquitin family
- actin-binding domain
- P domain
- CA domain
- Ubl1_cv_Nsp3_N-like
- Cdc42 binding domain
- IQ domain
- cofilin homology domain
- Ubiquitin homologues
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- alcoholic liver disease
- infection by HIV-1
role in cell
- binding in
- quantity
- formation
- tubulation
- extension
- polymerization
- generation
- assembly
- motility
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- invadopodia
- vesicles
- cytosol
- membrane ruffles
- sperm tail
- acrosome
- growth cone
- synaptosomes
- cell membrane leading edge
- perikaryon
- axons
- clathrin-coated vesicles
- lamellipodia
- microspikes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iqub gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- cilium morphogenesis
- mating
- smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- motile cilium
- radial spoke
- acrosomal vesicle
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein binding