Fnbp1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in bladder; central nervous system; dorsal root ganglion; and gut. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fnbp1 |
| Official Name | formin binding protein 1 [Source:MGI Symbol;Acc:MGI:109606] |
| Ensembl ID | ENSMUSG00000075415 |
| Bio databases IDs | |
| Aliases | formin binding protein 1 |
| Synonyms | 1110057E06RIK, 2210010H06RIK, FBP1, FBP17, Formin binding, formin binding protein 1, LOC102555088, LOC108348147, RAPOSTLIN, RND2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fnbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fes/CIP4, and EFC/F-BAR homology domain
- enzyme
- protein binding
- inserted domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Fnbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- juvenile rheumatoid arthritis
regulates
- actin
- TF
- DNM2
role in cell
- formation
- density
- morphology
- invasiveness
- invagination
- mesenchymal motility
- branching
- reorganization
- amoeboid motility
- invagination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- cytosol
- interchromatin granule clusters
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fnbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- intracellular membrane-bounded organelle
- coated pit
- cell cortex
- cytoplasmic vesicle
- cytosol
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding