Scara5 Gene Summary [Mouse]
Enables ferritin receptor activity. Involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Acts upstream of or within cellular response to heat. Located in cell surface and plasma membrane. Is expressed in several structures, including eye; gonad; heart; spinal cord; and vertebral pre-cartilage condensation. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scara5 |
| Official Name | scavenger receptor class A, member 5 [Source:MGI Symbol;Acc:MGI:1918395] |
| Ensembl ID | ENSMUSG00000022032 |
| Bio databases IDs | |
| Aliases | scavenger receptor class A, member 5 |
| Synonyms | 4932433F15Rik, 4933425F03Rik, NET33, RGD1306539, scavenger receptor class A member 5, scavenger receptor class A, member 5, Tesr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scara5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- cargo receptor activity
- Collagen triple helix repeat (20 copies)
- protein binding
- transmembrane receptor
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Scara5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- colorectal cancer
- diverticular disease
- deep vein thrombosis
- cutaneous melanoma
- diabetic nephropathy
- tinnitus
- thromboembolism
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- binding
- response by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- cell surface
- endoplasmic reticulum compartments
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scara5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- cellular response to heat
- protein homotrimerization
- endocytosis
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ferritin receptor activity