Riox1 Gene Summary [Mouse]
Enables histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of osteoblast differentiation; and regulation of DNA repair. Acts upstream of or within DNA repair and negative regulation of DNA repair. Located in nucleolus. Is expressed in skeleton and tibia cartilage condensation. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Riox1 |
| Official Name | ribosomal oxygenase 1 [Source:MGI Symbol;Acc:MGI:1919202] |
| Ensembl ID | ENSMUSG00000046791 |
| Bio databases IDs | |
| Aliases | ribosomal oxygenase 1 |
| Synonyms | 2410016O06Rik, C14orf169, hsNO66, JMJD9, MAPJD, MIRSA, NO66, RGD1307704, ribosomal oxygenase 1, ROX, URLC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Riox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate:oxygen oxidoreductase
- demethylase activity
- iron ion binding
- enzyme
- protein binding
- JmjC domain
- histone demethylase activity
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Riox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- histone demethylase activity (H3-K4 specific)
- histone demethylase activity (H3-trimethyl-K4 specific)
- peptidyl-histidine dioxygenase activity
- histone demethylase activity (H3-K36 specific)