Irs3

Enables phosphatidylinositol 3-kinase activator activity and phosphatidylinositol 3-kinase binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human IRS3P (insulin receptor substrate 3, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Irs3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.