Irs3 Gene Summary [Rat]

Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Irs3
Official Name
insulin receptor substrate 3 [Source:RGD Symbol;Acc:69317]
Ensembl ID
ENSRNOG00000001389
Bio databases IDs NCBI: 84021 Ensembl: ENSRNOG00000001389
Aliases insulin receptor substrate 3
Synonyms insulin receptor substrate 3
Species
Rat, Rattus norvegicus
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Irs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • phosphoinositide 3-kinase binding
  • insulin receptor binding
  • PTB domain (IRS-1 type)
  • PH domain
  • phosphoinositide 3-kinase regulator
  • phosphotyrosine binding domain
  • Pleckstrin homology-like domain
  • phosphorylation site

Pathways

Biological processes and signaling networks where the Irs3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • diabetes mellitus
  • insulin resistance
  • hyperplasia
  • hyperglycemia
  • hyperinsulinism
  • early-onset severe lipoatrophy
  • growth failure
regulated by
regulates
role in cell
  • apoptosis
  • survival
  • differentiation
  • mass
  • G1/S phase transition

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • plasma membrane fraction
  • nuclear fraction
  • low-density microsomal fraction
  • Plasma Membrane
  • cytosolic fraction