Irs4 Gene Summary [Mouse]
Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irs4 |
| Official Name | insulin receptor substrate 4 [Source:MGI Symbol;Acc:MGI:1338009] |
| Ensembl ID | ENSMUSG00000054667 |
| Bio databases IDs | |
| Aliases | insulin receptor substrate 4 |
| Synonyms | CHNG9, insulin receptor substrate 4, PY160, RP6 24A236 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irs4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- protein domain specific binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Irs4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- nongoitrous congenital hypothyroidism type 9
- insulin resistance
role in cell
- phosphorylation in
- activation in
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- detergent-soluble membrane fractions
- membrane fraction
- membrane surface
- Nucleus
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irs4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein binding
- insulin receptor binding