C2cd3 Gene Summary [Mouse]
Involved in centriole elongation. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and protein localization to centrosome. Located in centriolar satellite; centriole; and ciliary basal body. Is expressed in several structures, including alimentary system mesenchyme; brain; face; oral epithelium; and perichondrium. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XIV. Orthologous to human C2CD3 (C2 domain containing 3 centriole elongation regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C2cd3 |
| Official Name | C2 calcium-dependent domain containing 3 [Source:MGI Symbol;Acc:MGI:2142166] |
| Ensembl ID | ENSMUSG00000047248 |
| Bio databases IDs | |
| Aliases | C2 calcium-dependent domain containing 3 |
| Synonyms | C2 calcium-dependent domain containing 3, C2 domain containing 3 centriole elongation regulator, LOC277939, OFD14, RGD1307366 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C2cd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- daughter centriole
- mother centriole
- centriolar satellite
- basal bodies
- centrosome
- centriole
- cytosol
- centriolar appendages
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C2cd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- cilium morphogenesis
- in utero embryonic development
- regulation of proteolysis
- heart looping
- protein processing
- neural plate axis specification
- brain development
- protein localization to centrosome
- regulation of smoothened signaling pathway
- embryonic digit morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cilium basal body
- centriolar satellite
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding