Ttbk2 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in cilium assembly; hindbrain development; and smoothened signaling pathway. Acts upstream of or within several processes, including embryonic brain development; nervous system development; and positive regulation of non-motile cilium assembly. Located in ciliary base; ciliary transition zone; and microtubule organizing center. Is expressed in several structures, including nervous system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttbk2 |
| Official Name | tau tubulin kinase 2 [Source:MGI Symbol;Acc:MGI:2155779] |
| Ensembl ID | ENSMUSG00000090100 |
| Bio databases IDs | |
| Aliases | tau tubulin kinase 2 |
| Synonyms | 2610507N02RIK, AI326283, B930008N24Rik, KIAA0847, mKIAA0847, SCA11, tau tubulin kinase 2, TTBK, Ttbk1, TTK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttbk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Tau-protein kinase
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- microtubule plus-end binding
- protein binding
- Protein kinase domain
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spinocerebellar ataxia 11
role in cell
- quantity
- phosphorylation in
- migration
- survival
- binding
- assembly
- shrinkage
- organization
- ciliogenesis in
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- cilia
- Nucleus
- basal bodies
- centriole
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttbk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar granular layer development
- cilium morphogenesis
- signal transduction
- cerebellum development
- cerebellar granule cell precursor tangential migration
- smoothened signaling pathway
- negative regulation of microtubule depolymerization
- microtubule cytoskeleton organization
- peptidyl-serine phosphorylation
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cilium basal body
- centriole
- cytosol
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- tau protein binding
- microtubule plus-end binding
- kinesin binding
- protein kinase activity
- protein serine/threonine kinase activity