Cmya5 Gene Summary [Mouse]
Enables identical protein binding activity and protein phosphatase inhibitor activity. Acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade and regulation of skeletal muscle adaptation. Located in costamere. Is expressed in heart; skeletal muscle; and somite. Orthologous to human CMYA5 (cardiomyopathy associated 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmya5 |
| Official Name | cardiomyopathy associated 5 [Source:MGI Symbol;Acc:MGI:1923719] |
| Ensembl ID | ENSMUSG00000047419 |
| Bio databases IDs | |
| Aliases | cardiomyopathy associated 5 |
| Synonyms | 2310076E16Rik, 2310076E21Rik, C5orf10, cardiomyopathy associated 5, LOC683555, Myospryn, SPRYD2, sr553, Srfsd, Tims, TRIM76 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmya5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- protein phosphatase inhibitor activity
- B-box-type zinc finger superfamily
- B-Box C-terminal domain
- SPRY domain
- FN3
- coiled-coil domain
- B box/coiled coil domain
- protein binding
- Fibronectin type 3 domain
- Box B domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- schizophrenia
- anhedonia
- cardiac fibrosis
- lipofuscinosis
- perivascular fibrosis
role in cell
- quantity
- abnormal morphology
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- lysosome
- Endoplasmic Reticulum
- costameres
- sarcomere
- cytosol
- sarcoplasm
- nuclear speckles
- m-bands
- intercalated disks
- sarcolemma
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmya5 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- sarcoplasmic reticulum
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- cytosol
- M band
- plasma membrane