Tnni1 Gene Summary [Mouse]
Predicted to enable actin binding activity. Acts upstream of or within transition between fast and slow fiber and ventricular cardiac muscle tissue morphogenesis. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; brain; heart; musculature; and otocyst. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tnni1 |
| Official Name | troponin I, skeletal, slow 1 [Source:MGI Symbol;Acc:MGI:105073] |
| Ensembl ID | ENSMUSG00000026418 |
| Bio databases IDs | |
| Aliases | troponin I, skeletal, slow 1 |
| Synonyms | 2700018B22Rik, Slow tni, SSTNI, TNN1, Tnni, troponin I1, slow skeletal type, troponin I, skeletal, slow 1, Troponin I slow |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnni1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Troponin
- protein binding
Pathways
Biological processes and signaling networks where the Tnni1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- atrial fibrillation
- electrical alternation of heart
role in cell
- tension
- relaxation
- morphology
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnni1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transition between fast and slow fiber
- skeletal muscle contraction
- ventricular cardiac muscle tissue morphogenesis
- cardiac muscle contraction
- regulation of striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytosol
- troponin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding