Psmc4 Gene Summary [Mouse]
Predicted to enable proteasome-activating activity. Acts upstream of or within blastocyst development. Part of proteasome accessory complex. Is expressed in several structures, including cranial ganglion; early conceptus; gonad; liver lobe; and submandibular gland primordium. Used to study amyotrophic lateral sclerosis. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc4 |
| Official Name | proteasome (prosome, macropain) 26S subunit, ATPase, 4 [Source:MGI Symbol;Acc:MGI:1346093] |
| Ensembl ID | ENSMUSG00000030603 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
| Synonyms | CIP21, MIP224, PROTEASOMAL ATPASE TAT-binding protein 7, proteasome 26S subunit, ATPase 4, proteasome (prosome, macropain) 26S subunit, ATPase, 4, PRS6B, RPT3, S6, S6B, TBP-7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- walker type B motif
- peptidase
- walker type A motif
- leucine zipper domain
- protein binding
- AAA domain (Cdc48 subfamily)
- AAA+ lid domain
- ATPase
- helicase domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- HbYX motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- astrocytosis
- microgliosis
- infection by HIV-1
role in cell
- cell viability
- cell death
- growth
- proliferation
- loss
- formation
- quantity
- degeneration
- accumulation in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- basal bodies
- cytosol
- nucleoplasm
- synapse
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- blastocyst development
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- membrane
- cytosol
- cytosolic proteasome complex
- proteasome complex
- proteasome accessory complex
- synapse
- inclusion body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding