Dlk2 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlk2 |
| Official Name | delta like non-canonical Notch ligand 2 [Source:MGI Symbol;Acc:MGI:2146838] |
| Ensembl ID | ENSMUSG00000047428 |
| Bio databases IDs | |
| Aliases | delta like non-canonical Notch ligand 2 |
| Synonyms | delta like non-canonical Notch ligand 2, EGFL9, δ like non-canonical Notch ligand 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of fat cell differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- calcium ion binding
- Notch binding