DLK2 Gene Summary [Human]
Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DLK2 |
| Official Name | delta like non-canonical Notch ligand 2 [Source:HGNC Symbol;Acc:HGNC:21113] |
| Ensembl ID | ENSG00000171462 |
| Bio databases IDs | |
| Aliases | delta like non-canonical Notch ligand 2 |
| Synonyms | delta like non-canonical Notch ligand 2, EGFL9, δ like non-canonical Notch ligand 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of fat cell differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- calcium ion binding
- Notch binding