Mtbp Gene Summary [Mouse]
Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; cerebral cortex subventricular zone; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtbp |
| Official Name | Mdm2, transformed 3T3 cell double minute p53 binding protein [Source:MGI Symbol;Acc:MGI:2146005] |
| Ensembl ID | ENSMUSG00000022369 |
| Bio databases IDs | |
| Aliases | Mdm2, transformed 3T3 cell double minute p53 binding protein |
| Synonyms | LOC102552118, MDM2 binding protein, MDM2BP, Mdm2, transformed 3T3 cell double minute p53 binding protein, RGD1565672 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- MDM2-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- lymphomagenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- gastritis
- hepatitis A
- neoplastic cell transformation
role in cell
- formation
- proliferation
- cell death
- migration
- survival
- colony formation
- migratory capacity
- transformation
- S phase
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- negative regulation of cell proliferation
- protein localization to kinetochore
- traversing start control point of mitotic cell cycle
- regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- kinetochore
- chromatin