Atg16l2 Gene Summary [Mouse]
Involved in autophagosome assembly. Acts upstream of or within negative stranded viral RNA replication. Located in cytosol and phagophore assembly site membrane. Part of Atg12-Atg5-Atg16 complex. Is expressed in embryo. Orthologous to human ATG16L2 (autophagy related 16 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Atg16l2 |
| Official Name | autophagy related 16-like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1920933] |
| Ensembl ID | ENSMUSG00000047767 |
| Bio databases IDs | |
| Aliases | autophagy related 16-like 2 (S. cerevisiae) |
| Synonyms | 2410118P20Rik, ATG16B, autophagy related 16-like 2, RGD1311400, WDR80 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg16l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar FliJ protein
- Autophagy protein 16 (ATG16)
- WD40 repeats
- UDM1_RNF168_RNF169-like
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- WD domain, G-beta repeat
- WD40
- protein binding
- Flagellar protein FliT
- Cell division protein ZapB
- TolA binding protein trimerization
Pathways
Biological processes and signaling networks where the Atg16l2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- gallstone
- thromboembolism
- infection by HIV-1
- infection by Citrobacter rodentium
- productive infection by HIV-1
role in cell
- apoptosis
- macroautophagy in
- autophagy in
- number
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg16l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- protein transport
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- Atg12-Atg5-Atg16 complex
- cytosol
- autophagic vacuole
- nucleoplasm