Rab33b Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Involved in autophagosome assembly. Located in Golgi lumen. Used to study Smith-McCort dysplasia 2. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Orthologous to human RAB33B (RAB33B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rab33b |
| Official Name | RAB33B, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1330805] |
| Ensembl ID | ENSMUSG00000027739 |
| Bio databases IDs | |
| Aliases | RAB33B, member RAS oncogene family |
| Synonyms | RAB33, RAB33B, member RAS oncogene family, SMC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab33b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Smith-McCort dysplasia type 2
- peripheral arterial disease
regulates
role in cell
- formation
- replication in
- vesicle transport in
- assembly
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- Golgi lumen
- presynaptic regions
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab33b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization in Golgi apparatus
- regulation of cell growth
- Rab protein signal transduction
- protein transport
- regulation of retrograde vesicle-mediated transport, Golgi to ER
- intra-Golgi vesicle-mediated transport
- regulation of exocytosis
- regulation of epithelial cell proliferation
- skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- endosome
- Golgi membrane
- Golgi apparatus
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity