ATG16L2 Gene Summary [Human]
Predicted to be involved in autophagosome assembly and negative stranded viral RNA replication. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATG16L2 |
| Official Name | autophagy related 16 like 2 [Source:HGNC Symbol;Acc:HGNC:25464] |
| Ensembl ID | ENSG00000168010 |
| Bio databases IDs | |
| Aliases | autophagy related 16 like 2 |
| Synonyms | 2410118P20Rik, ATG16B, autophagy related 16-like 2, RGD1311400, WDR80 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATG16L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar FliJ protein
- Autophagy protein 16 (ATG16)
- WD40 repeats
- UDM1_RNF168_RNF169-like
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- WD domain, G-beta repeat
- WD40
- protein binding
- Flagellar protein FliT
- Cell division protein ZapB
- TolA binding protein trimerization
Pathways
Biological processes and signaling networks where the ATG16L2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- gallstone
- thromboembolism
- infection by HIV-1
- infection by Citrobacter rodentium
- productive infection by HIV-1
role in cell
- apoptosis
- macroautophagy in
- autophagy in
- number
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATG16L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- protein transport
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- Atg12-Atg5-Atg16 complex
- cytosol
- autophagic vacuole
- nucleoplasm