Adgrl2 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and PDZ domain binding activity. Involved in synapse organization. Acts upstream of or within positive regulation of synapse assembly and response to bacterium. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in central nervous system; future brain; and heart. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrl2 |
| Official Name | adhesion G protein-coupled receptor L2 [Source:MGI Symbol;Acc:MGI:2139714] |
| Ensembl ID | ENSMUSG00000028184 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor L2 |
| Synonyms | adhesion G protein-coupled receptor L2, CIRL-2, CL2, Cl2ac, Gm619, LATROPHILIN 2, LEC1, LOC101927458, LPHH1, LPHN2, mKIAA0786 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- Olfactomedin-like domain
- GPCR-Autoproteolysis INducing (GAIN) domain
- Latrophilin Cytoplasmic C-terminal region
- GPCR proteolysis site, GPS, motif
- Galactose/rhamnose-binding lectin domain
- Galactose binding lectin domain
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- Alzheimer disease
- cancer
- glomerulonephritis
- gastric cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- cataract
- pervasive developmental disorder
- single ventricle defect
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- migration
- invasion by
- Gap 0-Gap 1 phase
- epithelial-mesenchymal transition
- exocytosis by
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- postsynaptic membrane
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- latrotoxin receptor activity
- G-protein coupled receptor activity
- carbohydrate binding