Adgrl1 Gene Summary [Mouse]
Predicted to enable cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in growth cone and synapse. Predicted to be active in axon; glutamatergic synapse; and presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrl1 |
| Official Name | adhesion G protein-coupled receptor L1 [Source:MGI Symbol;Acc:MGI:1929461] |
| Ensembl ID | ENSMUSG00000013033 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor L1 |
| Synonyms | 2900070I05Rik, adhesion G protein-coupled receptor L1, AI182398, CIRL1, CL1, CL1BA, CLIBA, DEDBANP, LEC2, LOC101928805, LPHN1, mKIAA0821 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- GPCR-Autoproteolysis INducing (GAIN) domain
- cell adhesion molecule binding
- latrotoxin receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- Olfactomedin-like domain
- Latrophilin Cytoplasmic C-terminal region
- GPCR proteolysis site, GPS, motif
- Galactose/rhamnose-binding lectin domain
- Galactose binding lectin domain
- toxin binding
Pathways
Biological processes and signaling networks where the Adgrl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- cancer
- developmental delay, behavioral abnormalities, and neuropsychiatric disorders
- Alzheimer disease
- hereditary disorder
- preeclampsia
- fasting hyperinsulinemia
- global developmental delay
- insulin resistance
- hemangioma
regulates
- L-glutamic acid
- alpha-latrotoxin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- growth cone
- neurites
- nerve ending
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- heterophilic cell-cell adhesion
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- growth cone
- membrane
- synapse
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- latrotoxin receptor activity
- G-protein coupled receptor activity
- protein binding
- cell adhesion molecule binding
- carbohydrate binding