Nmt1 Gene Summary [Mouse]
Enables glycylpeptide N-tetradecanoyltransferase activity. Acts upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Nmt1 |
| Official Name | N-myristoyltransferase 1 [Source:MGI Symbol;Acc:MGI:102579] |
| Ensembl ID | ENSMUSG00000020936 |
| Bio databases IDs | |
| Aliases | N-myristoyltransferase 1 |
| Synonyms | AW536594, HsNMT1, NMT, N-myristoyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidyl-lysine N6-myristoyltransferase
- Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
- Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
- myristoyltransferase
- enzyme
- protein binding
- glycylpeptide N-tetradecanoyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cardiovascular disorder
- liver cirrhosis
- gastric cancer
- organismal death
- insomnia
- enteritis
- Goldenhar syndrome
- dyslexia
- white matter hyperintensities
role in cell
- differentiation
- phosphorylation in
- cell viability
- migration
- development
- number
- binding
- invasion by
- influx in
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular ketone metabolic process
- in utero embryonic development
- protein localization in membrane
- N-terminal peptidyl-glycine N-myristoylation
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidyl-lysine N6-myristoyltransferase activity
- glycylpeptide N-tetradecanoyltransferase activity
- myristoyltransferase activity