Gp5 Gene Summary [Mouse]
Enables collagen binding activity. Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Predicted to be located in cell surface. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in several structures, including hepatic primordium; liver; mesenchyme derived from splanchnopleure; placenta; and yolk sac. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gp5 |
| Official Name | glycoprotein 5 (platelet) [Source:MGI Symbol;Acc:MGI:1096363] |
| Ensembl ID | ENSMUSG00000047953 |
| Bio databases IDs | |
| Aliases | glycoprotein 5 (platelet) |
| Synonyms | CD42d, glycoprotein 5 platelet, glycoprotein V platelet, glycoprotein V (platelet), Glycoprotein V Precursor, GPV, NEWGENE 2724, PLGPV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- collagen binding
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
regulates
- Ca2+
- PLA2G4A
- thromboxane A2
- Fibrinogen
- Collagen type I (complex)
role in cell
- production in
- adhesion
- aggregation
- activation
- inhibition
- binding
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- blood coagulation, intrinsic pathway
- megakaryocyte development
- cell adhesion
- release of sequestered calcium ion into cytosol
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding