NEWGENE_2724 Gene Summary [Rat]
Predicted to enable collagen binding activity. Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to act upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Located in cell surface. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_2724 |
| Official Name | glycoprotein V platelet [Source:RGD Symbol;Acc:11377642] |
| Ensembl ID | ENSRNOG00000038540 |
| Bio databases IDs | |
| Aliases | glycoprotein V platelet |
| Synonyms | CD42d, glycoprotein 5 platelet, glycoprotein V platelet, glycoprotein V (platelet), Glycoprotein V Precursor, GPV, NEWGENE 2724, PLGPV |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_2724 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- collagen binding
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
regulates
- Ca2+
- PLA2G4A
- thromboxane A2
- Fibrinogen
- Collagen type I (complex)
role in cell
- production in
- adhesion
- aggregation
- activation
- inhibition
- binding
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_2724 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- blood coagulation, intrinsic pathway
- megakaryocyte development
- cell adhesion
- release of sequestered calcium ion into cytosol
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding