Kcna1 Gene Summary [Mouse]
Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to magnesium ion; detection of mechanical stimulus involved in sensory perception; and nervous system development. Located in several cellular components, including axon; cell surface; and perikaryon. Part of voltage-gated potassium channel complex. Is active in axon initial segment. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Used to study epilepsy; episodic ataxia type 1; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna1 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, member 1 [Source:MGI Symbol;Acc:MGI:96654] |
| Ensembl ID | ENSMUSG00000047976 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, member 1 |
| Synonyms | AEMK, Brain K+ channel protein 1, EA1, HBK1, HUK1, HUKI, Kca1-1, Kcna, Kcpvd, KV1.1, KV 1.1 alpha subunit, KV 1.1 α subunit, MBK1, mceph, MK1, potassium voltage-gated channel, shaker-related subfamily, member 1, potassium voltage-gated channel subfamily A member 1, RBK1, Shak, Voltage-gated potassium channel protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- voltage-gated potassium channel
- subregion I of the P region
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein domain specific binding
- protein binding
- voltage-gated ion channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- episodic ataxia type 1
- multiple sclerosis
- Huntington disease
- nonarteritic ischemic optic neuropathy
- seizures
- ventricular extrasystole
- tremor
- myokymia
role in cell
- expression in
- proliferation
- invasion by
- transmembrane potential
- oncogene-induced senescence
- response by
- action potential
- ferroptosis
- response
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell junction
- axon component
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- nodes of Ranvier
- axonal membrane
- paranodes
- juxtaparanodes
- inner mesaxons
- internodes
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- membrane repolarization involved in regulation of action potential
- potassium ion transmembrane transport
- neuromuscular process
- protein localization
- protein homooligomerization
- hippocampus development
- cerebral cortex development
- corpus callosum development
- optic nerve development
- neuroblast proliferation
- regulation of membrane potential
- startle response
- cellular response to magnesium ion
- regulation of muscle contraction
- neuronal signal transduction
- cell communication by electrical coupling
- detection of mechanical stimulus involved in sensory perception of pain
- regulation of action potential
- detection of mechanical stimulus involved in sensory perception of touch
- magnesium ion homeostasis
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- paranode region of axon
- voltage-gated potassium channel complex
- endoplasmic reticulum
- neuronal cell body
- juxtaparanode region of axon
- synapse
- perikaryon
- plasma membrane
- axon terminus
- cell surface
- calyx of Held
- dendrite
- initial segment
- anchoring junction
- postsynaptic membrane
- membrane
- cytosol
- cytoplasmic vesicle
- cell junction
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- delayed rectifier potassium channel activity