Sptbn4 Gene Summary [Mouse]
Enables actin binding activity and spectrin binding activity. Involved in protein localization. Acts upstream of or within several processes, including adult walking behavior; neuron development; and regulation of heart contraction. Located in axon; cell body fiber; and intercalated disc. Is active in juxtaparanode region of axon and node of Ranvier. Is expressed in several structures, including liver; neural ectoderm; optic vesicle; spinal cord lateral wall; and spleen. Orthologous to human SPTBN4 (spectrin beta, non-erythrocytic 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sptbn4 |
| Official Name | spectrin beta, non-erythrocytic 4 [Source:MGI Symbol;Acc:MGI:1890574] |
| Ensembl ID | ENSMUSG00000011751 |
| Bio databases IDs | |
| Aliases | spectrin beta, non-erythrocytic 4 |
| Synonyms | 1700022P15Rik, 5830426A08Rik, Beta iv sigma 1, Beta iv sigma 4 spectrin, Beta IV spectrin, CMND, dyn, lnd, NEDHND, nmf261, nmf379, QV, ROSA62, SpbIV, spectrin beta, non-erythrocytic 4, spectrin, beta, non-erythrocytic 4, Spectrin β IV, spectrin β, non-erythrocytic 4, spectrin, β, non-erythrocytic 4, SPNB4, SPTBN3, ΒIV-spectrin, β iv σ 1, β iv σ 4 spectrin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sptbn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- CaMKII binding domain
- Calponin homology domain
- protein binding activity, bridging
- spectrin binding
- protein binding
- Pleckstrin homology-like domain
- cytoskeletal adaptor
- chromosome segregation protein SMC, common bacterial type
- Spectrin repeats
- structural constituent of cytoskeleton
- ankyrin binding
- actin binding
- Spectrin repeat
- PH domain
- calponin homology (CH) domain superfamily
- phosphatase binding
Pathways
Biological processes and signaling networks where the Sptbn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- congenital myopathy with neuropathy and deafness
- acute myeloid leukemia
- renal cell carcinoma
- renal cell cancer
- hereditary disorder
- dysmetria
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- expression in
- phosphorylation in
- development
- formation
- transmission
- abnormal morphology
- instability
- potentiation
- fertilization
- diameter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axon component
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- actin filaments
- intercellular junctions
- cytosol
- nuclear foci
- nuclear bodies
- nuclear matrix
- nodes of Ranvier
- axon hillock
- neurites
- axon initial segments
- anchoring junction
- gap junctions
- PML nuclear bodies
- perikaryon
- axons
- cell-cell adherens junctions
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sptbn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- neuromuscular process
- fertilization
- central nervous system projection neuron axonogenesis
- cardiac conduction
- positive regulation of multicellular organism growth
- neuromuscular junction development
- clustering of voltage-gated sodium channels
- sensory perception of sound
- adult walking behavior
- regulation of sodium ion transport
- vesicle-mediated transport
- actin filament capping
- axonogenesis
- negative regulation of heart rate
- regulation of peptidyl-serine phosphorylation
- actin cytoskeleton organization
- transmission of nerve impulse
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- paranode region of axon
- PML body
- neuronal cell body
- juxtaparanode region of axon
- actin filament
- cell projection
- axon hillock
- plasma membrane
- adherens junction
- initial segment
- extracellular vesicular exosome
- cytoplasm
- membrane
- cell body fiber
- nuclear matrix
- intercalated disc
- cell junction
- cytosol
- node of Ranvier
- spectrin
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatase binding
- protein binding
- spectrin binding
- actin binding
- ankyrin binding
- structural constituent of cytoskeleton
- phospholipid binding