Fut4 Gene Summary [Mouse]
Enables alpha-(1->3)-fucosyltransferase activity. Involved in lymphocyte migration into lymph node; positive regulation of leukocyte tethering or rolling; and positive regulation of neutrophil migration. Located in cell periphery and cell surface. Is expressed in several structures, including central nervous system; ear; extraembryonic component; genitourinary system; and respiratory system. Orthologous to human FUT4 (fucosyltransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fut4 |
| Official Name | fucosyltransferase 4 [Source:MGI Symbol;Acc:MGI:95594] |
| Ensembl ID | ENSMUSG00000049307 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 4 |
| Synonyms | AI451562, CD15, ELAM-1 LIGAND FUCOSYLTRANSFERASE, FAL, FCT3A, fucosyltransferase 4, Fuct, FUC-TIV, FUTIV, LeX, SSEA-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fut4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha(1,3)-fucosyltransferase
- hexosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Pathways
Biological processes and signaling networks where the Fut4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malignant pleural mesothelioma
- prostate cancer
- epithelial cancer
- mesothelioma formation
- classical Hodgkin lymphoma
- classic Hodgkin disease
- primary mediastinal large B-cell lymphoma
- primary cancer
- mediastinal cancer
- B-cell non-Hodgkin disease
role in cell
- apoptosis
- activation in
- proliferation
- dimerization in
- migration
- quantity
- binding
- number
- cellular infiltration by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fut4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- lymphocyte migration into lymph node
- inflammatory response
- fucosylation
- protein glycosylation
- oligosaccharide biosynthetic process
- oligosaccharide metabolic process
- L-fucose catabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
- cell periphery
- cell surface
Molecular Function
What the gene product does at the molecular level
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- fucosyltransferase activity
- alpha-(1->3)-fucosyltransferase activity