FUT4 Gene Summary [Human]
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | FUT4 |
| Official Name | fucosyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:4015] |
| Ensembl ID | ENSG00000196371 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 4, galactoside 3-L-fucosyltransferase, alpha (1,3) fucosyltransferase, myeloid-specific |
| Synonyms | AI451562, CD15, ELAM-1 LIGAND FUCOSYLTRANSFERASE, FAL, FCT3A, fucosyltransferase 4, Fuct, FUC-TIV, FUTIV, LeX, SSEA-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha(1,3)-fucosyltransferase
- hexosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Pathways
Biological processes and signaling networks where the FUT4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malignant pleural mesothelioma
- prostate cancer
- epithelial cancer
- mesothelioma formation
- classical Hodgkin lymphoma
- classic Hodgkin disease
- primary mediastinal large B-cell lymphoma
- primary cancer
- mediastinal cancer
- B-cell non-Hodgkin disease
role in cell
- apoptosis
- activation in
- proliferation
- dimerization in
- migration
- quantity
- binding
- number
- cellular infiltration by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- lymphocyte migration into lymph node
- inflammatory response
- fucosylation
- protein glycosylation
- oligosaccharide biosynthetic process
- oligosaccharide metabolic process
- L-fucose catabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
- cell periphery
- cell surface
Molecular Function
What the gene product does at the molecular level
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- fucosyltransferase activity
- alpha-(1->3)-fucosyltransferase activity