Tmie Gene Summary [Mouse]
Acts upstream of or within inner ear morphogenesis and sensory perception of sound. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Orthologous to human TMIE (transmembrane inner ear). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmie |
| Official Name | transmembrane inner ear [Source:MGI Symbol;Acc:MGI:2159400] |
| Ensembl ID | ENSMUSG00000049555 |
| Bio databases IDs | |
| Aliases | transmembrane inner ear |
| Synonyms | 5131400L21Rik, DFNB6, Mm.87012, RGD1562523, sr, transmembrane inner ear |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmie often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TMIE protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 6
- autosomal recessive deafness
- familial nonsyndromic hearing impairment
- autosomal recessive nonsyndromic hearing loss
- ear malformation
- sensorineural hearing loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmie gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inner ear morphogenesis
Cellular Component
Where in the cell the gene product is active
- membrane