Trim54 Gene Summary [Mouse]
Enables microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Part of microtubule associated complex. Is expressed in several structures, including diaphragm; heart; lung; skeletal musculature; and trunk dermomyotome. Orthologous to human TRIM54 (tripartite motif containing 54). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim54 |
| Official Name | tripartite motif-containing 54 [Source:MGI Symbol;Acc:MGI:1889623] |
| Ensembl ID | ENSMUSG00000062077 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 54 |
| Synonyms | 4930486E09Rik, 4930566I02Rik, MURF, MURF-3, RNF30, tripartite motif-containing 54 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim54 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- microtubule binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- zinc finger of C3HC4-type, RING
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- coiled-coil domain
- Ring finger domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac hypertrophy
- myopathy
- hypertrophic cardiomyopathy
- bleeding
- dilated cardiomyopathy
role in cell
- migration
- apoptosis
- expression in
- differentiation
- abnormal morphology
- depolymerization
- ubiquitination in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim54 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell differentiation
- negative regulation of microtubule depolymerization
- protein ubiquitination
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- Z disc
- cytoplasm
- microtubule associated complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- microtubule binding