Sarm1 Gene Summary [Mouse]
Enables NAD+ nucleosidase activity. Involved in several processes, including NAD catabolic process; regulation of dendrite morphogenesis; and regulation of synapse pruning. Acts upstream of or within regulation of neuron apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrial outer membrane. Part of protein-containing complex. Is active in cell surface and neuromuscular junction. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sarm1 |
| Official Name | sterile alpha and HEAT/Armadillo motif containing 1 [Source:MGI Symbol;Acc:MGI:2136419] |
| Ensembl ID | ENSMUSG00000050132 |
| Bio databases IDs | |
| Aliases | sterile alpha and HEAT/Armadillo motif containing 1 |
| Synonyms | A830091I15RIK, hSARM1, HsTIR, MyD88-5, SAMD2, SARM, sterile alpha and HEAT/Armadillo motif containing 1, sterile alpha and TIR motif containing 1, sterile α and HEAT/Armadillo motif containing 1, sterile α and TIR motif containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sarm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- N-glycosyl glycosylase
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- SEFIR domain
- NAD nucleosidase
- protein binding
- Fungal symportin 1 (syo1) and similar proteins
- TIR domain
- identical protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- focal cortical dysplasia type I
- axonal degeneration
- uterine leiomyoma
- leiomyomatosis
- amyotrophic lateral sclerosis
- muscular atrophy
- sporadic amyotrophic lateral sclerosis
- structural anomaly
- cognitive impairment
role in cell
- expression in
- production in
- cell death
- survival
- activation in
- size
- number
- accumulation in
- apoptosis
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- microtubule cytoskeleton
- Cytoplasm
- cell surface
- cellular membrane
- Mitochondria
- microtubules
- cytosol
- mitochondrial outer membrane
- neuromuscular junctions
- growth cone
- synapse
- photoreceptor inner segments
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sarm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
- response to axon injury
- regulation of neuron apoptotic process
- regulation of dendrite morphogenesis
- response to glucose stimulus
- protein localization in mitochondrion
- innate immune response
- cell differentiation
- neurological system process
- NAD catabolic process
- negative regulation of MyD88-independent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- mitochondrion
- cytosol
- macromolecular complex
- synapse
- mitochondrial outer membrane
- axon
- microtubule
- cell surface
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- NAD(P)+ nucleosidase activity
- protein binding
- signaling adaptor activity